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|Title: ||Calcium Absorption in Nigerian Children with Rickets|
|Authors: ||Graff, Mariaelisa|
Thacher, Tom D.
Fischer, Philip R.
Pam, Sunday D.
Pettifor, John M.
Isichei, Christian O.
Abrams, Steven A.
|Keywords: ||Stable isotopes|
dietary calcium deficiency
intestinal calcium absorption
|Issue Date: ||2004|
|Publisher: ||The American Journal of Clinical Nutrition|
|Series/Report no.: ||Vol. 80;Pp 1415-1421|
|Abstract: ||Background: Nutritional rickets is common in Nigerian children and
responds to calcium supplementation. Low dietary calcium intakes are
also common in Nigerian children with and without rickets.
Objective: The objective was to assess intestinal calcium absorption
in Nigerian children with rickets.
Design: Calcium absorption was assessed in 15 children with active
rickets (2–8 y of age) and in 15 age- and sex-matched children
without rickets by using a dual-tracer stable-isotope method. The
children with rickets were supplemented with calcium for 6 mo;
calcium absorption was reevaluated 12 mo after the baseline study.
Fractional calcium absorption could be determined in 10 children
with rickets and in 10 children without rickets.
Results: The children with and without rickets had dietary calcium
intakes of 200 mg/d. Compared with the control children, the
children with rickets had lower serum 25-hydroxyvitamin D and
calcium concentrations and greater 1,25-dihydroxyvitamin D and
parathyroid hormone concentrations. In fact, there were 15 rachitic
and 15 control children in the study. Mean ( SD) fractional calcium
absorption did not differ between those with (61 20%) and without
(63 13%) rickets (P 0.47). Calcium absorption was not associated
with serum concentrations of calcium, alkaline phosphatase,
25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, or parathyroid
hormone. Mean fractional calcium absorption was significantly
greater after (81 10%) than before (61 20%) calcium supplementation
for the treatment of rickets (P 0.035).
Conclusions: In Nigerian children with rickets, the capacity to absorb
calcium is not impaired; however, fractional calcium absorption
increases after the resolution of active disease. Calcium absorption
may be inadequate to meet the skeletal demands of children with
rickets during the active phase of the disease, despite being similar
to that of control children.|
|Appears in Collections:||Paediatrics|
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