University of Jos Institutional Repository >
Medical Sciences >
Paediatrics >

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/984

Title: Serum Levels of the Pyridinoline Crosslinked Carboxyterminal Telopeptide of Type 1 Collagen (ICTP) and Osteocalcin in Rachitic Children in Nigeria.
Authors: Scariano, John K.
Walter, Elizabeth A.
Glew, Robert H.
Hollis, Bruce W.
Henry, Allison
Ocheke, Isaac
Isichei, Christien O.
Keywords: Rickets
Bone resorption
collagen metabolism
Biological markers
metabolic bone disease
Issue Date: 1995
Publisher: Clinical Biochemistry
Series/Report no.: Vol. 28;No.5; Pp 541-545
Abstract: Objectives: We measured the levels of the pyridinoline crosslinked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) in the serum of 12 rachitic and 27 healthy Nigerian children, and compared the performance of these relatively new markers of bone metabolism with estab- lished laboratory parameters of skeletal disease. Design and Methods: Active rickets was diagnosed on the basis of clinical and biochemical criteria. Serum calcium and phos- phorus concentration and alkaline phosphatase activity were determined using clinically accepted methods. Radioimmuno- assay was performed to quantify parathyroid hormone, 1-,25- dihydroxyvitamin D, OC, and ICTP. Results: The rachitic children had statistically significant serum elevations of ICTP and osteocalcin as compared with age- and sex-matched controls. Serum levels of ICTP correlated with al- kaline phosphate activity. Conclusions: As a marker of abnormal bone metabolism, ICTP performs at least as well as alkaline phosphate. ICTP and OC are valuable additions to the growing repertoire of bone markers.
URI: http://hdl.handle.net/123456789/984
Appears in Collections:Paediatrics

Files in This Item:

File Description SizeFormat
1-s2.0-0009912095000439-main.pdf544.02 kBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback