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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1463

Title: Mass ivermectin Treatment for Onchocerciasis: Lack of Evidence for Collateral Impact on Treansmission of Wuchereria Bancrofti in Areas of Co-endemicity.
Authors: Richards, F.O.
Eigege, A.
Pam, D.
Kal, A.
Lenhart, A.
Oneyka, J.O.A.
Jinadu, M.Y.
Miri, E.S.
Issue Date: 15-Jul-2005
Publisher: Filaria Journal
Series/Report no.: Vol. 4;No. 6
Abstract: There has long been interest in determining if mass ivermectin administration for onchocerciasis has 'unknowingly' interrupted lymphatic filariasis(LF) transmission where the endemicity of the two diseases' overlaps. We studied II communities in central Nigeria entomologically for LF by performing mosquito dissections on Anopheline LF vectors. Six of the communities studied were located within an onchocerciasis treatment zone, and five were located outside of that zone. Communities inside the treatment zone had been offered ivermectin treatment for two-five years, with a mean coverage of 81% of the eligible population (range 58-95%). We found 4.9% of mosquitoes were infected with any larval stage of W. bancrofti in the head or thorax in 362 dissections in the untreated villafes compared to 4.7% infected in 549 dissections in ivermectin treated villages (Mantel-Haenszel ChiSquare 0.02, P = 0.9). We concluded that ivermectin annual therapy for onchocerciasis has not interrupted transmission of Wuchereria bancrofti (the causative agent of LF in Nigeria).
URI: http://hdl.handle.net/123456789/1463
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