The Effect of Deisopropylngaione on the Renal Function in Sheep

Abstract

Following intoxication of sheep with 150 mg/kg body weight of Deisopropylngaione [DIN] intra-peritoneally. there was impaimient ofthc renal function as depicted by decreases in the glomcrular filtration rate |GFR]. renal plasma flow [RPF] and tubular transport maximum for glucose [TMG] which were essentially pre-renal in origin. The mean feed intake, free water intake and urine output also decreased following intoxication ofsheep with DIN. There were increases in the plasma aspertate transferase [ASTl. alkaline phosphatase [ALP] and plasma creatinine post exposure to DIN. The mean values for plasma sodium, potassium and chloride concentrations showed no significant differences following intoxication with deisopropylngaione in sheep.