University of Jos Institutional Repository >
Natural Sciences >
Please use this identifier to cite or link to this item:
|Title: ||Demographic and Clinical Correlates of HIV-1 RNA Levels in Antiretroviral Therapy-Naive Adults Attending a Tertiary Hospital in Jos, Nigeria|
|Authors: ||Anejo-Okopi, Joseph|
Abah, Isaac Okoh
Ebonyi, Augustine Odo
Isa, Samson Ejiji
Idoko, John A.
|Keywords: ||viral load|
CD4+ cell count
|Issue Date: ||2017|
|Publisher: ||Journal of Virus Eradication|
|Series/Report no.: ||Vol. 3;Pp 51–55|
|Abstract: ||Background: Plasma HIV-RNA viral load (VL) of HIV-infected persons is an important prognostic factor in HIV management.
We determined the VL among antiretroviral therapy (ART)-naive patients to identify the association between patients’
demographic, clinical and laboratory characteristics with VL.
Method: A cross-sectional study of 224 ART-naive HIV-1-infected patients (≥15 years of age) accessing care at the Jos
University Teaching Hospital AIDS Prevention Initiative in Nigeria ART treatment centre, from October 2010 to April 2011.
A log-linear model was used to determine if VL was related to demographic and clinical variables.
Results: The patients had a median (interquartile range) age of 34 (28–41) years with females in the majority (59%).
Females compared to males and pulmonary tuberculosis (PTB) co-infected compared to not co-infected patients had a
significantly higher VL (14.9 loge versus 11.5 loge, P=0.003 and 11.31 loge versus 11.89 loge, P=0.047, respectively). VL
tended to decrease with increasing CD4+ cell count levels in females, but remained relatively unchanged in males across
all values of CD4+ cell counts. The difference (β) in the mean change in VL between males and females was loge 0.64
Conclusion: In ART-naive HIV-1-infected patients in our setting, females had significantly higher VL and lower CD4+
cell count, at the same VL threshold, compared to males, and hence were more likely to be at a higher risk of rapid progression
to AIDS. Therefore, gender-based strategies for early identification and engaging females into care are required in this
setting to mitigate against rapid progression to AIDS.|
|Appears in Collections:||Microbiology|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.