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|Title: ||Prevalence, Clinical Features and Outcome of Neonatal Malaria in Two Major Hospitals in Jos, North-Central Nigeria|
|Authors: ||Diala, Udochukwu M.|
Onyedibe, Kenneth I.
Ofakunrin, Akinyemi O. D.
Diala, Olubunmi O.
|Issue Date: ||2017|
|Publisher: ||Advances in Infectious Diseases|
|Citation: ||Diala, U.M., Onyedibe, K.I., Ofakunrin, A.O.D., Diala, O.O., Toma, B., Egah, D. and Oguche, S. (2017) Prevalence, Clinical Features and Outcome of Neonatal Malaria in Two Major Hospitals in Jos, North-Central Nigeria. Advances in Infectious Diseases , 7, 55-69. https://doi.org/10.4236/aid.2017.73007|
|Series/Report no.: ||Vol.7;No.3: Pp 55-69|
|Abstract: ||Malaria was thought to be rare in neonates. However, recent studies report
increasing prevalence in neonates. Clinical features of neonatal malaria have
also not been adequately reported. This study was undertaken to assess the
prevalence, clinical features and outcome of malaria in neonates admitted into
two tertiary hospitals in Jos, Plateau State. All consecutive neonates aged 0 -
28 days admitted into the neonatal units of Jos University Teaching Hospital
and Bingham University Teaching Hospital, Jos were recruited into the study.
Giemsa stained blood films of the neonates were examined by trained microscopists.
Neonates with malaria had presenting clinical features recorded and
treated with amodiaquine (1st line) and quinine (2nd line). Clinical features and
parasitaemia were monitored for 14 days for outcome. Of the 301 neonates
enrolled, 16 had malaria parasitaemia giving a prevalence of 5.3%. Congenital
malaria accounted for 87.5% of cases of neonatal malaria. Plasmodium falciparum
mono-infection was responsible for all the cases of malaria. ITN use in
pregnancy offered some protection against neonatal malaria (CI = 0.2 - 0.7).
The median parasite density was 255 (72, 385) parasites/μl. Fever was significantly
present in 10 (66.7%) of the cases (p = 0.03). Fifteen of the 16 neonates
had clinical and parasitological cure on treatment with amodiaquine. One
treatment failure had cure after retreatment with quinine. There was no mortality
in all 16 neonates treated for malaria. Malaria is not rare in neonates on
admission in Jos. Fever is the commonest clinical feature of neonatal malaria.
Amodiaquine provided effective treatment of malaria in neonates in Jos.|
|Appears in Collections:||Paediatrics|
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