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|Title: ||Antiviral Activity of the Fruit Extract of Cucumis metuliferus E. Meye (Curcubitaceae) in Chicks|
|Authors: ||Wannang, Noel N.|
Ede, Samuel O.
Kwanashie, Helen O.
|Issue Date: ||2010|
|Publisher: ||African Journal of Basic and Applied Sciences|
|Citation: ||Pp 89-93|
|Series/Report no.: ||Vol.2;No.3-4|
|Abstract: ||Aim of Study: Antiviral property of the alkaloidal components of fruit extract of Cucumis
metuliferus E. Meye (100-600 mg/kg) was evaluated in chicks infected with newcastle disease.
Materials and Method: The alkaloidal component of the fruit extract was investigated for antiviral
properties in chicks. The birds were infected with a virulent strain of newcastle disease virus and the
following were examined: physical signs of clinical illness, time of death and histopathological examination of
the culprit organs of infection (proventriculus, ventriculus and caecum) and compared with control groups.
Results: The result showed that the alkaloids isolated from the plant material were capable of reducing
and/or reversing the effects of the virus in chicks. Conclusion: The study showed that the alkaloidal
component of this fruit is a potent antiviral agent since it prevented and reversed virus induced manifestations
in infected chicks.|
|Appears in Collections:||Pharmacology|
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