Effect of C. metuliferus on some Metabolic Parameters in wistar strain albino rats

Abstract

The effects of the fruit extract of C. metuliferus on the Water and food intake, feacal and urine output were monitored daily for a period of four weeks in albino rats. The weight of the animals were also taken daily during the entire study period. The result showed that there were dose dependent changes in body weight of the experimental rats, which were not statistically significant (P>0.05). 500 mg/kg of the extract produced an increased in food intake of the experimental rats while 1000 mg/kg produced decreased in food consumption of the rats, however, these changes were not statistically significant (P>0.05). On the other hand, increased in water intake showed significant difference compared to the control (P<0.05). There was no significant difference (P>0.05) in the faecal output of rats in the treated groups. The decrease in urine output in the animals administered 500 mg/kg was statistically significant (P<0.05); so also the increased in urine output in rats treated with 1000 mg/kg. There was an insignificant increased (P>0.05) in electrolyte concentration (Na+ and K+) in the 500 mg/kg treated group compared to that of control. On the contrary, 1000 mg/kg showed significant (P<0.05) decreased in electrolyte concentrations