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|Title: ||Calcium Supplements Increase the Serum Levels of Crosslinked N-Telopeptides of Bone Collagen and Parathyroid Hormone in Rachitic Nigerian Children|
|Authors: ||Scariano, John K.|
Vanderjagt, Dorothy J.
Isichei, Christian O.
Hollis, Bruce W.
Glew, Robert H.
|Issue Date: ||1998|
|Publisher: ||Clinical Biochemistry|
|Series/Report no.: ||Vol.31;No.5; Pp 421–427|
|Abstract: ||Objectives: Biochemical markers of bone turnover were measured
in the sera of 16 controls and 10 children with calcium-deficiency
rickets, during a 12-week course of calcium supplementation (1 g
CaCO3/d) that was effective in healing the bone lesions of the
Design and methods: Serum levels of crosslinked N-telopeptides
of bone collagen (NTx), parathyroid hormone (PTH), alkaline phosphatase
(ALP), and urinary deoxypyridinoline (LP) were assayed at
baseline and during the course of calcium therapy and compared
with data of the 16 non-rachitic controls.
Results: Calcium therapy suppressed serum NTx and PTH levels in
the rachitic children within 24 h; however, after the first week, PTH
and NTx levels increased to the extent that at 12 weeks both were
elevated when compared with controls or to baseline levels. Serum
levels of NTx and PTH were correlated in the controls and experimental
subjects (r 5 0.63, p , 0.001).
Conclusions: The rate of bone resorption, as estimated by serum
NTx concentration, is increased during the healing of rachitic
lesions. Copyright © 1998 The Canadian Society of Clinical Chemists|
|Appears in Collections:||Chemical Pathology|
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