Effects of Aqueous Extract of Ipomoea batatas Leaf on Blood Glucose, Kidney Functions and Hematological Parameters of Streptozotocin-Induced Diabetic Rats

Abstract

Diabetes mellitus as reported by is a complex disorder that affects metabolism in humans and other subjects, affecting several organs in the system. Management of diabetes is challenging and its treatments are often associated with side effects as scientist is increasingly demanding for natural products with antidiabetic activity and fewer side effects [1,2]. In this study, the effect of aqueous Ipomoea batatas leaf extract was carried out in streptozotocin- induced diabetic rats (55 mg/ kg) body wt. for 28days. The continuous administration of extract from 400 mg/ kg body wt. for 28days signifi cantly (P ˂ 0.05) reversed the effects on blood glucose which was initially increased. There was a signifi cant decrease (P ˂ 0.05) in urea, creatinine, and uric which show kidney impairment following induction of the diabetogen. There was signifi cant increase (P ˂ 0.05) in the PCV, Hb, RBC, Neutrophils, Basophils, and Monocytes. While Wbc, platelets, lymphocytes, and Eosinophils were signifi cantly (P ˂ 0.05) decreased. The study therefore reveals that aqueous Ipomoea batatas leaf extract can be used in hyperglycemia management as well as in improvement in kidney and blood hematological functions.