Anticonvulsant Activity of Some N, N'-(2,3,5,6- Tetramethyl-l,4-Phenylene) Bis (4-Substituted Benzamides)

Abstract

The anticonvulsant activity of four analogues of N,N'-(2,3,5,6-tetramethyl-I,4-phenylene) bis (4- substitutedbenzamides) were determined at three dose levels in accordance with the Antiepleptic Drug Development program (ADD) of National Institute of Health (NIH), USA. These compounds are analogues of 4-amino-N-(2,6- dimethylphenyl)benzamide (Ameltolide®, or LY20 1116) which is the most potent benzamide anticonvulsant studied to date. The result of our anticonvulsant screening confirmed the superiority of 4-aminobenzamides over other parasubstituted analogues.