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|Title: ||Epidemiology of Neural Tube Defects in North Central Nigeria|
|Authors: ||Uba, A.F|
|Keywords: ||aetiological factors,|
|Issue Date: ||2004|
|Publisher: ||African Journal of Paediatrics Surgery|
|Series/Report no.: ||Vol.1;No.1;Pp 16-19|
|Abstract: ||Background: Neural tube defects (NTDs) are associated
with high childhood morbidity worldwide. We wanted to know
the pattern and the possible aetiological factors responsible
for this anomaly in northcentral Nigeria.
Patients and Methods: The clinical records of all children
with NTD admitted at JUTH between 1986 and 2003 were
reviewed and the data analyzed for age, gender and antenatal
care, incidence, type and location of lesion.
Results: There were 284 patients (144 males and 140 females).
The incidence of NTD was 0.5/1000 live births and
1.9% of all admissions. The Hausa / Fulani ethnic group
constituted the highest proportion. In 165 (58%) patients,
the mothers had received antenatal care; however, the antenatal
care generally started late in pregnancy. Spina bifida
constituted 97% of the total NTDs, 79.6% of which were
meningomyeloceles. The sites mostly affected were the lumbosacral and the thoracolumbar regions in 55.8% and
31.9% of cases, respectively. Hydrocephalus was the most
common complication occurring in 194 (68.3%) patients.
Among those patients presenting with myelomeningocele,
95 (42%) had ruptured sacs, while in 62 (27.4%) the sacs
were ulcerated and locally infected; 15 (6.6%) patients had
meningitis while 16 (7.1%) had septicemia.
Conclusion: The most common type of NTD in this study
was lumbosacral myelomeningocele, the majority of which
were complicated at presentation. Consanguinity marriage
and delayed or absence of antenatal care appear to be important
|Appears in Collections:||Surgery|
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