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|Title: ||Serum Levels of the Pyridinoline Crosslinked Carboxyterminal Telopeptide of Type I Collagen (ICTP) and Osteocalcin in Rachitic Children in Nigeria|
|Authors: ||Scariano, John K.|
Walter, Elizabeth A.
Glew, Robert H.
Hollis, Bruce W.
Isichei, Christien O.
metabolic bone disease.
|Issue Date: ||Oct-1995|
|Publisher: ||Clinical Biochemistry|
|Series/Report no.: ||Vol.28;No.5; Pp 541-545|
|Abstract: ||Objectives: We measured the levels of the pyridinoline
crosslinked carboxyterminal telopeptide of type I collagen
(ICTP) and osteocalcin (OC) in the serum of 12 rachitic and 27
healthy Nigerian children, and compared the performance of
these relatively new markers of bone metabolism with established
laboratory parameters of skeletal disease.
Design and Methods: Active rickets was diagnosed on the basis
of clinical and biochemical criteria. Serum calcium and phosphorus
concentration and alkaline phosphatase activity were
determined using clinically accepted methods. Radioimmunoassay
was performed to quantify parathyroid hormone, 1-,25-
dihydroxyvitamin D, OC, and ICTP.
Results: The rachitic children had statistically significant serum
elevations of ICTP and osteocalcin as compared with age- and
sex-matched controls. Serum levels of ICTP correlated with alkaline
Conclusions: As a marker of abnormal bone metabolism, ICTP
performs at least as well as alkaline phosphate. ICTP and OC are
valuable additions to the growing repertoire of bone markers.|
|Appears in Collections:||Paediatrics|
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