University of Jos Institutional Repository >
Medical Sciences >
Paediatrics >

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/769

Title: Serum Levels of the Pyridinoline Crosslinked Carboxyterminal Telopeptide of Type I Collagen (ICTP) and Osteocalcin in Rachitic Children in Nigeria
Authors: Scariano, John K.
Walter, Elizabeth A.
Glew, Robert H.
Hollis, Bruce W.
Henry, Allison.
Ocheke, Isaac
Isichei, Christien O.
Keywords: rickets,
bone resorption.
collagen metabolism,
biological markers,
metabolic bone disease.
Issue Date: Oct-1995
Publisher: Clinical Biochemistry
Series/Report no.: Vol.28;No.5; Pp 541-545
Abstract: Objectives: We measured the levels of the pyridinoline crosslinked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) in the serum of 12 rachitic and 27 healthy Nigerian children, and compared the performance of these relatively new markers of bone metabolism with established laboratory parameters of skeletal disease. Design and Methods: Active rickets was diagnosed on the basis of clinical and biochemical criteria. Serum calcium and phosphorus concentration and alkaline phosphatase activity were determined using clinically accepted methods. Radioimmunoassay was performed to quantify parathyroid hormone, 1-,25- dihydroxyvitamin D, OC, and ICTP. Results: The rachitic children had statistically significant serum elevations of ICTP and osteocalcin as compared with age- and sex-matched controls. Serum levels of ICTP correlated with alkaline phosphate activity. Conclusions: As a marker of abnormal bone metabolism, ICTP performs at least as well as alkaline phosphate. ICTP and OC are valuable additions to the growing repertoire of bone markers.
URI: http://hdl.handle.net/123456789/769
Appears in Collections:Paediatrics

Files in This Item:

File Description SizeFormat
Serum Levels of the Pyridinoline.pdf544.02 kBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback