University of Jos Institutional Repository >
Pharmaceutical Sciences >
Please use this identifier to cite or link to this item:
|Title: ||Diuretic activity of Ageratum conyzoides extract in rats|
|Authors: ||Falang, Kakjing Dadul|
Azi, Iliya Hosea
Chukwurah, Chiago Joy
|Keywords: ||urine electrolytes|
|Issue Date: ||2012|
|Series/Report no.: ||Vol. 3;No. 1; Pp 145-149|
|Abstract: ||The diuretic effect of the aqueous extract of the leaves of Ageratum conyzoides was
evaluated in albino Wistar rats. Thirty rats in six groups were used for the study.
Aqueous extract at three dose levels (200,400 and 600mg/kg), Frusemide and Acetazolamide
were used as standard drugs while distilled water was used for control.
Parameters studied included total urine volume after 24 hours, pH and urine concentration
of sodium, potassium and chloride ions. We found LD50 to be greater than
5000mg/kg. The leaf extract exhibited significant (P<0.01) diuretic activity. At the
end of 24 hours, 200, 400 and 600mg/kg of extract produced 7.60±0.68, 7.00±0.45
and 6.80±0.49ml of urine respectively. The pH of urine produced by the extract and
standard drugs were all alkaline. At a dose of 600mg/kg body weight, there was significant
(P<0.01) increase in concentrations of sodium, potassium and chloride
ions. This could be important in the treatment of cardiovascular diseases such as hypertension.
The results suggested that the leaf extract of A. conyzoides has diuretic
properties similar to Acetazolamide.|
|Appears in Collections:||Pharmacology|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.