Family Medicine

Permanent URI for this collectionhttps://irepos.unijos.edu.ng/handle/123456789/11487

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Start date: 2007End date: 2009

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    A Comparison of Sulfadoxine-Pyrimethamine with Chloroquine and Pyrimethamine for Prevention of Malaria in Pregnant Nigeria Women
    (The American Society of Tropical Medicine and Hygiene, 2007) IBRAHIM U. TUKUR; TOM D. THACHER; ATIENE S. SAGAY,; JEREMIAH K. A. MADAKI
    Abstract. Few studies have documented the effectiveness in west Africa of intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine (SP) in pregnancy. Pregnant Nigerian women were assigned to receive either SP given twice or presumptive chloroquine (CQ) treatment followed by weekly pyrimethamine (CQ + P); 250 were enrolled in each group. Of those completing follow-up, 4 (1.8%) in the SP group and 22 (9.8%) in the CQ + P groups had a febrile illness (P 0.005). None in the SP group but 11 (4.9%) in the CQ + P group had peripheral parasitemia prior to or during delivery (P 0.002). Two (1.2%) in the SP group and 9 (5.0%) in the CQ + P group were anemic at delivery (P 0.04). There were six low birth weight infants in the SP group and eight in the CQ + P group (P 0.21). Intermittent preventive treatment with SP is superior to CQ + P for prevention of malaria and anemia in pregnant women in Nigeria.