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Item Therapeutic Efficacy of Quinapyramine Sulphate with Freund’s Complete Adjuvant in Wistar Rats Infected with Trypanosoma Congolense(DAVID PUBLISHING, 2017) Ehizibolo, P. O.; Karaye, G. P.; Kadima, K. B.; Lawal, I. A.; Okubanjo, O. O.; Aliu, Y. O.Therapeutic efficacy of QS (quinapyramine sulphate) and FCA (Freund’s complete adjuvant) combination was studied. The aim of the study was to evaluate therapeutic efficacy of QS using FCA in Trypanosoma congolense infection. Groups treated with QS and FCA had parasite disappeared in peripheral circulation 2 days pi, relapse was observed one week later. Effect of treatment on rectal temperature shows no significance (p < 0.05), normalization of rectal temperature occurred in QS and FCA treated groups (34.1 ℃) than untreated (42.8 ℃), QS (37.4 ℃) and FCA (35.92 ℃) treated groups. Mean body weight was significant (p < 0.001) in QS and FCA, QS, and FCA groups. Packed cell volume and hemoglobin concentration for untreated groups were lower, but increased in QS, FCA, QS and FCA treated groups, indicating anemia amelioration. White blood cell counted in untreated, QS and FCA treated groups showed no significance (p < 0.05), however, there was leukocytosis due to lymphocytosis in QS and FCA treated group (6.79 × 103/μl) compared with untreated and other groups. There was comparative decrease in serum liver enzymes in QS and FCA treated group than other groups. Therefore, QS at lower recommended dose with FCA may enhance efficacy of QS in trypanosomiasis.Item Prevalence of Swine Gastrointestinal Parasites in Four Selected Local Government Areas of Nasarawa State, Nigeria(International Journal of Livestock Research, 2016-01-01) Karaye, G. P.; Dogo, A. G.; Iliyasu, D.; Madu, H. K.Gastrointestinal parasitic infections in swine are one of the major challenges in pig production in Nigeria. It causes substantial reproductive losses, poor reproductive performance and production in swine industry. Internal parasites are known to deteriorate the wellbeing of pigs by robbing the essential nutrients that are required for optimum reproduction and productivity. It also injured some vital organs which play key role in metabolic activities and assimilation process. The consequences are anorexia, poor growth rate, anaemia, emaciation, infertility and condemnation of affected organs after slaughter. The study was designed to collect two hundred feacal samples from 4 local government area (Laminga, Tammah, Nasarawa and Kusa) of Nasarawa state between (March to July 2015). Fifty samples were randomly collected from each local government areas within the study period. The samples collected were evaluated microscopically for different prevalence of gastro intestinal parasites GIT in pigs. Five species of gastrointestinal parasites were identified with prevalence of 13.5 % for Ascaris suum and strongyloides while Fasciola, trichuris suis cyst and Oesophagustomum oocyst had a prevalence of 7.5 % and 2.5 % respectively. A prevalence of 61.5 % was observed as overall species prevalence in the 200 fecal samples analysed. Therefore, there is a need for combined efforts to control parasites infections for optimum production of pigs and prevention of zoonotic helminthiasis.