EFFECT OF AQUEOUS SOYABEAN EXTRACT AND METFORMIN ON SOME BIOCHEMICAL PARAMETERS IN ALLOXAN- INDUCED DIABETIC RATS

Abstract

Soya bean is a staple food with great nutritional value. In this study, the effect of aqueous soya bean extract was carried out in Alloxan induced diabetic rats for 7days. The phytochemical screening indicated the presence of alkaloids, flavonoids, tannins, cardiac glycosides, terpenes, steroids, phenols and resins. Diabetic rats exhibited high blood glucose, cholesterol, Triglyceride (TG) and Low Density Lipoprotein (LDL) while High Density Lipoprotein (HDL) was very low. The continuous administration of extract at150 mg/kg b.wt. for 7 days significantly (P˂0.05) reverse these effects on cholesterol, TG, HDL and LDL while a similar result was also observe for metformin (14.2 mg/kg b.wt) treated group. The extract had no significant effect (P˃0.05) on serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) while serum alkaline phosphatase (ALP) was significantly increasing (P˂0.05) when compared to the control. Although the extract could not significantly lower the blood glucose when compared to the control, a gradual reduction was observed on day7. The present study revealed that aqueous soya bean extract can effectively control some of the metabolic disorders that are associated with diabetic.